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HONG KONG, CHINA – EQS Newswire – 18 September 2020 – The board of directors (the “Board”) of Uni-Bio Science Group Limited (the “Company”, together with its subsidiaries, the “Group”) is pleased to announce updates on the developmental potential of the Group’s innovative biologic self-developed drug Recombinant Exendin-4 Injection (“Uni-GLP”).
Uni-GLP, a class of glucagon-like peptide-1 receptor agonists (“GLP-1 RAs”), can reduce high blood glucose by increasing insulin and decreasing glucagon secretion, is effective in the treatment of Type 2 diabetes mellitus (“T2DM”). GLP-1 RAs are particularly advantageous because of their incretin effect which can lower risk of hypoglycemia. In addition, GLP-1 RAs is one of the only classes of diabetic drugs shown to cause significant weight loss. The application for clinical trial of Uni-GLP submitted by the Company has been accepted by National Medical Products Administration (“NMPA”) on 14 July 2020. Currently, the Group’s professional and technical personnel are making great efforts to prepare for clinical trial-related works.
New Progress and Opportunities of GLP-1 RAs
Based on new data presented in the scientific community, GLP-1 RAs can treat a wide range of high value indications such as obesity, cardiovascular disease (“CVD”), nonalcoholic fatty liver disease (“NAFLD”) and nonalcoholic steatohepatitis (“NASH”), Alzheimer’s disease (“AD”), as well as new coronavirus disease 2019 (“COVID-19”; caused by severe acute respiratory syndrome coronavirus 2, “SARS-CoV-2”), where there are significant unmet medical needs.
As obesity is a common comorbidity of T2DM, this class is effective in T2DM patients who are overweight, accounting for at least 30% of all diabetes patients in the PRC according to IMS primary research. In addition, GLP-1 RAs has further been shown to have beneficial impact on cardiovascular function independent of its role in peripheral glycemic control, through increasing myocardial glucose uptake, preserving myocardial function following ischemic injury. Moreover, evidence suggests that GLP-1 secretion is impaired in patients with NAFLD and NASH-the aggressive form of NAFLD that can lead to cirrhosis and hepatocellular carcinoma, highlighting the role of GLP-1 RAs as potential candidates for NAFLD treatment. Furthermore, emerging evidences have shown that AD, caused by “starvation” of the brain, is associated with insulin resistance. When the brain cannot use glucose due to insulin resistance, it can lead to inflammation and deposition of plaques and tangles. Nevertheless, GLP-1 RAs can prevent the decline of brain glucose consumption, causing synaptogenesis and neurogenesis, thereby improving memory behavior.
Most recently, it has been hypothesized that GLP-1 RAs have been considered excellent candidates for the treatment of patients with COVID-19 with or without T2DM owing to their multiple beneficial effects on excessive inflammation-induced acute lung injury. Multiple preclinical studies performed in mice and rats with experimental induced lung injury demonstrated that GLP-1 RAs attenuate pulmonary inflammation, through inhibitory activity on cytokine release, as a result of their interference with nuclear factor-κB (“NF-κB”) signaling pathways. More recently, several studies have demonstrated the capacity of GLP-1 RAs to enhance the activity of the angiotensin converting enzyme 2 (“ACE2”)→ angiotensin (1–7)（”A(1–7)”）→Mas receptor (“MasR”) axis by directly stimulating ACE2 expression would contribute to reduce the progression of inflammatory and thrombotic processes frequently associated with the poor prognosis of SARS-CoV-2 infection, through the fostering of an antithrombotic and anti-inflammatory milieu. Lung injury and inflammation is seen in more severe COVID-19 infected patients, and a leading cause of COVID-19 related fatalities. The advantage compared with vaccine is that the GLP-1 RAs can continue to protect lung function even when coronavirus mutates.
Next Steps for Uni-GLP
The Board is optimistic about Uni-GLP’s potential in new therapeutic areas. The Group has already kicked off partnerships with several universities in PRC to conduct preclinical research of Uni-GLP in obesity, as well as to formulate a new innovative oral or 3rd generation Uni-GLP. Armed with the recent data of GLP-1 RA in treatment of CVD, NAFLD, NASH, AD and COVID-19, the Group is currently in talks with NMPA and prospective partners to expand Uni-GLP into these new areas.
About Uni-Bio Science Group Limited
Uni-Bio Science Group Limited is principally engaged in the research and development, manufacture and distribution of pharmaceutical products. The research and development center is fully equipped with a complete system for the development of genetically-engineered products with a pilot plant test base which is in line with NMPA requirements. The Group also has two GMP manufacturing bases in Beijing and Shenzhen. The Group is focused on the development of novel treatments and innovative drugs addressing the therapeutic areas of diabetes, ophthalmology and dermatology.
Uni-Bio Science Group Limited was listed on the Main Board of the Hong Kong Stock Exchange on November 12, 2001. Stock code: 0690.
As part of the expanded global Pathways to
Progress initiative, Citi and the Citi Foundation to collectively invest US$35
million in philanthropic contributions and grants to improve the employability
of youth from low-income and underserved communities in Asia by 2023
- Citi Asia Pacific to offer 6,000 jobs and 60,000
job-skills training opportunities for youth over the next three years
Young people to continue to be positioned front and center in tackling
most pressing challenges in Asia and accelerating progress towards the United Nations’
Sustainable Development Goals (SDGs)
HONG KONG, CHINA – Media OutReach – 18 September 2020 – Citigroup Inc. (NYSE: C) – Citi Asia Pacific and the Citi
Foundation today announced a collective commitment of US$35 million in philanthropic investments
to advance economic opportunities and employability for youth from low-income
and underserved communities in the region by 2023. In addition, the bank will offer 6,000 jobs
and 60,000 job skills training opportunities for young people at Citi Asia over
the next three years.
commitments are part of Citi’s expanded global Pathways to Progress initiative. This initiative is designed to equip young people with the
skills and confidence to improve their employment and entrepreneurship
opportunities and make a positive impact in their lives and their communities
commitment is in response to the impact of COVID-19 on youth employment in the
region. According to the International Labor Organization (ILO), Asia Pacific
is home to more than half of the world’s youth population, with 700 million
youth aged 15 to 24 years. While they represent 20 per cent of the total
working-age population, this youth segment accounts for almost half of the Asia
Pacific’s jobless. The pandemic and resulting economic crisis has further
challenged this issue. Projections through the end of 2020 in 13 countries show
sizable jumps, with youth unemployment rates doubling the 2019 rate in some
“Communities in Asia Pacific are facing a youth
unemployment crisis, especially among low-income and underserved groups, due to
the impact of COVID-19. The expanded Pathways to Progress initiative underlines
our effort to tackle this urgent issue by equipping and empowering young people
with skills to improve their employment outcomes. Young people are key to Asia
Pacific’s COVID-19 recovery and this investment will help them advance their
economic opportunities and support inclusive growth in the region,” said Peter
Babej, Citi’s Asia Pacific CEO.
On its employment and
training, Citi has committed to over the next three years to offer 6,000
jobs and 60,000 skills training opportunities across Citi’s retail and
institutional businesses in Asia Pacific through its summer internship program,
full-time analyst and associate roles, on-campus programs and opportunities
with Citi® University Partnerships in Innovation & Discovery
The CUPID program engages diverse students on a range of innovation
projects across the company. To provide students
the opportunity to experience banking despite the pandemic, Citi Asia Pacific
launched a first-of-its-kind Virtual Reality Intern Experience program, open
for enrolment to students around the world.
The program offers ‘lifelike’ on-the-job tasks and skills training
relevant to an analyst role across three different businesses at Citi – Banking,
Capital Markets and Advisory (BCMA), Markets and Securities Services, and
Citi Foundation grant investments
will focus on programs that serve low-income and underserved communities who have been disproportionately
impacted by COVID-19, including young women at risk, migrant youth, minorities and youth
addition, Pathways to Progress programming on youth leadership and innovation will be strengthened, to recognize the
role youth can play in enabling progress and finding solutions for the most
pressing challenges faced by society.
In Asia Pacific, examples of Pathways to Progress programming
funded in 2020 include:
Co:Lab, a project co-created by Citi Foundation and the United Nations
Development Programme (UNDP), to continue bringing governments and stakeholders
together to support young social entrepreneurs in starting and growing
businesses that accelerate achievement of the United Nations’ Sustainable
Development Goals in more than 25 countries and territories across the region
- Citi’s US$10 million commitment in India to deliver
demand-driven future skills training to 200,000 low-income youth and providing
at least 70% of them with employment across India’s growth industries
- Paid internships
supported by Citi through Hong Kong Council of Social Services and Kyung Hee
University in South Korea to provide university students the opportunity to
gain work experiences at nonprofit organizations
- Citi Foundation partnership
with AIME in Australia to help Indigenous high school youth further their
education or transition to job training and employment
- Citi Foundation partnership
with the Philippine Business for Education through First Future, which unlocks
the first careers of K to 12 graduates by connecting education to concrete
Foundation partnership with UCEP Bangladesh to ensure decent employment of
underprivileged women by providing demand-driven skills training, nationally
recognized certification and job placement support
Foundation partnership with The Garden of Hope Foundation in Taiwan to help
teenage girls who have experienced domestic violence or exploitation to explore
future employment opportunities and professional interests
Foundation partnership with UNESCO in Indonesia to build an enabling ecosystem
and contribute to sustainable livelihoods for young entrepreneurs in creative
industries living in and around Indonesia’s heritage sites
Since 1999, the Citi
Foundation, has been actively engaged across Asia Pacific, investing over $280
million in grant funds. In Pathways to
Progress: Insights from Six Years of Programming, the Citi
Foundation summarizes the learnings
and insights gathered that have helped inform the programming and evolution of
Pathways to Progress also engages thousands of Citi employee volunteers,
who lend their time and talent to serve as mentors, coaches and role models to
many young people.
Tackling the COVID-19 youth employment crisis in
Asia and the Pacific: ILO and ADB, 2020
the leading global bank, has approximately 200 million customer accounts and
does business in more than 160 countries and jurisdictions. Citi provides
consumers, corporations, governments and institutions with a broad range of
financial products and services, including consumer banking and credit,
corporate and investment banking, securities brokerage, transaction services,
and wealth management.
may be found at www.citigroup.com | Twitter: @Citi | YouTube: www.youtube.com/citi | Blog: http://blog.citigroup.com | Facebook: www.facebook.com/citi | LinkedIn: www.linkedin.com/company/citi.
Citi Foundation works to promote economic progress and improve the lives of
people in low-income communities around the world. We invest in efforts that increase
financial inclusion, catalyze job opportunities for youth, and reimagine
approaches to building economically vibrant communities. The Citi Foundation’s
“More than Philanthropy” approach deploys the enormous expertise of
Citi and its people to fulfill our mission and drive thought leadership and
NAIROBI, KENYA – Media
OutReach – 18
September 2020 – Infinix, a global leader in consumer electronics
market, has launched the ZERO 8 in the Kenyan market. ZERO 8 is the company’s
flagship series for 2020/21. Though targeting the high-end market, Zero 8 will
retail at a relatively affordable price of Kshs 28,999.
launch has been conducted in partnership with Sally Karago, a renowned international fashion
designer. This partnership with a high-end designer is geared towards raising
the Infinix’s brand position and perception in the market as a high end phone.
This is also part of a broader push to combine tech with fashion to create
products that are a fusion of design and innovation.
“Infinix is taking a step to be more premium and
able to compete and be the face of this new direction as a fashion-conscious
brand. This direction is very much in tandem with our target customers, whose
lifestyle can be described as image and fashion-conscious and trendy, with a
taste for high end gadgets”, said Mike Zhang, Infinix Kenya Brand Manager.
Using her international acclaim and experience,
Sally has designed garments for the three celebrities who graced the launch,
namely the gorgeous songstress Tanasha Donna, celebrated chef Ali Mandhry and
Catherine Kamau, an award-winning actress. Inspired by the Turkana culture,
Sally’s fashion collection has been made using local African fabrics and beads
for accessories (all drawn from the Turkana culture). The design features
diamond-shaped elements which are the main design concept for the Zero 8 smartphone.
(From left, singer Tanasha Donna, Chef Ali Mandhry and actress Catherine Kamau)
The accessories, including beads, also drawn from
Sally’s Turkana collection experience, feature the main colours of the Infinix
brand, which are green, black, and white.
Explore more about the story https://youtu.be/ByjWM1xkf70
Tanasha Donna wearing the Sally Karago designed
garment for Infinix Zero 8 Launch
Sally also designed special shirts as uniforms to
be worn by Infinix sales representatives in various Infinix outlets. These
feature an ethnic fabric strip on the button section of the shirt. The ethnic
fabric color drawn from the Turkana culture is close to green, a key Infinix
brand color. They spot the Infinix brand
logo across the chest pocket region giving a simplistic finish and an appealing
look. These uniforms communicate a much-improved customer care approach to
Infinix consumers and are a symbol of improved brand professionalism.
Infinix sales representatives wearing the Sally
Karago designed shirts
stylish and fashion-focused Infinix Zero 8 runs on Android v10 operating system, with its key
feature being the presence of a Media Tek Helio G90
processor. This, combined with
128 GB ROM and 8 GB RAM, will enable consumers to experience improved speeds
and overall device performance, including quick upload and download times and
an amazing experience with the apps, compared to the Zero 6. The 90Hz Full HD
Display and G90T processor also means enhanced performance on the screen and
for the cameras, including the wide angle, ultra-wide angle and rear cameras
that will take photographic performance to a new level.
On the front, for the first time ever,
Infinix has released a device with two selfie cameras (48 + 8MP), fitting them
in a punch-hole setup. At the back, there’s a 64-megapixel main sensor
headlining the quad-camera setup housed in the diamond-style bump.
Smartphones have become
a key aspect in everyday life, enabling many people to run their businesses
from the comforts of their seats and giving them access to the outside world. Over the last few years, the partnership
between tech companies (especially device manufacturers), and fashion houses
has witnessed a tremendous growth.
Infinix is also set to venture into a new product
category with launched Infinix TV, aimed at fulfilling smart lifestyle living
in accordance with modern trends. With Android TV™, the high-quality viewing
experience, and the AIoT technology, the new smart TV will develop the new
business line for the company and take the entertainment of local customers to
a new level.
The Infinix X1 will retail at a relatively
affordable price of KES 31,990(43-inch)/KES 19,490(32-inch) and will be covered
by a guarantee policy of up to 24 months.
Mobile is a Shenzhen-based smartphone company founded in 2013 and a subsidiary
of Transsion. The brand was born after the French mobile manufacturer Sagem
Wireless was acquired in 2011. The company has Research and Development
(R&D) centres sprawling between France and Korea and designs its phones in
is committed to building cutting-edge technology and fashionably designed
dynamic mobile devices to create globally-focused intelligent life experiences
through a merging of fashion + technology.
the brand spirit of challenging the norms, Infinix smart devices are designed
specifically for young people who want to stand out, reach out and be in sync
with the world.
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